The DCLK2 Antibody (N-term) from MyBioSource.com is a Rabbit Polyclonal antibody to CLIK2. This antibody recognizes Human antigen. The DCLK2 Antibody (N-term) has been validated for the following applications: ELISA, and Western Blot.
Description
This gene encodes a member of the protein kinase
superfamily and the doublecortin family. The protein encoded by
this gene contains two N-terminal doublecortin domains, which bind
microtubules and regulate microtubule polymerization, a C-terminal
serine/threonine protein kinase domain, which shows substantial
homology to Ca2+/calmodulin-dependent protein kinase, and a
serine/proline-rich domain in between the doublecortin and the
protein kinase domains, which mediates multiple protein-protein
interactions. The microtubule-polymerizing activity of the encoded
protein is independent of its protein kinase activity. Mouse
studies show that the DCX gene, another family member, and this
gene share function in the establishment of hippocampal
organization and that their absence results in a severe epileptic
phenotype and lethality, as described in human patients with
lissencephaly. Multiple alternatively spliced transcript variants
have been identified